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open-science

by ai4s-research1.4kTypeScriptUpdated 2026-08-21

Open Science Desktop — local-first, model-agnostic AI research workbench for macOS, Windows & Linux. Open-source Claude Science desktop alternative built on Tauri + MCP + agent skills.

Open Science Desktop is a local-first, model-agnostic AI research workbench application for macOS, Windows, and Linux that runs autonomous scientific research workflows from exploration through publication. Built on Tauri, MCP, and OpenCode, it bundles specialized research agents (ai4s-agent, research-explorer, literature-survey, experiment-suite, paper-writer) that chain together to produce traceable, reproducible artifacts including figures, reports, and LaTeX papers. The desktop application provides a multi-pane interface with project management, persistent memory, headless server mode, and remote browser access, while maintaining complete data privacy by keeping all workspace files, session history, and provenance records local by default.

Key Features

Autonomous research agent pipeline that runs exploration → literature survey → experiment → paper writing with reproducible artifacts
Local-first architecture with all sessions, data, provenance, and run records stored in local folders
Model-agnostic runtime supporting any OpenCode-compatible provider (Claude, GPT-4, Gemini, local models)
Headless server mode (osd) for running the full workbench without a GUI, controllable via CLI or web UI on any device
Agent Client Protocol support for driving other ACP agents (Codex, Gemini CLI, Claude Code) or being driven from editors (Zed, JetBrains, Neovim)
Built-in browser automation that drives Chrome with your real profile and logins intact
Project-based workspace organization with global and per-project memory, searchable history, and context compaction
Bundled science MCP connectors for arXiv, PubMed, Crossref, Semantic Scholar, Materials Project, FRED, and weather/climate data

Use Cases

  • 01Running end-to-end scientific research workflows from initial exploration through manuscript preparation with full reproducibility
  • 02Conducting literature reviews with automated citation verification and DOI resolution across multiple academic databases
  • 03Designing and executing computational experiments with provenance tracking linking every figure and result to its generating code
  • 04Operating research workloads on remote compute (SSH, Slurm, Modal) from a local desktop interface
  • 05Reviewing research integrity by auditing papers for citation accuracy, statistical consistency, and figure/code traceability
  • 06Managing multiple concurrent research projects with isolated workspaces, per-project memory, and independent model configurations

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open-science — FAQ

What is Open Science Desktop?+

Open Science Desktop is an open-source AI research workbench application that runs autonomous research agents locally on macOS, Windows, and Linux. It provides a complete workflow from literature exploration to paper writing with full provenance tracking and reproducible artifacts.

How do I install Open Science Desktop?+

Download the installer for your platform from the GitHub releases page: .dmg/.app for macOS (13 Ventura or later), NSIS .exe for Windows 10/11, or .deb/.rpm for Linux x86_64. macOS builds are signed and notarized; Windows/Linux builds may show SmartScreen warnings.

What AI models does Open Science Desktop work with?+

Open Science Desktop is model-agnostic and works with any provider supported by OpenCode, including Claude (Anthropic), GPT-4 (OpenAI), Gemini (Google), and custom OpenAI-compatible endpoints. You configure provider API keys through the app settings or the osd CLI.

Do I need API keys to use Open Science Desktop?+

Yes, you need API keys for your chosen model provider (Anthropic, OpenAI, Google, etc.). Keys are stored in app-private runtime config on your machine and never leave your system by default. Set them via Settings in the desktop app or osd auth set <provider> --key in the CLI.

Is Open Science Desktop free and open source?+

Yes, Open Science Desktop is released under the MIT license and is free to use. You pay only for the API calls to your chosen model provider (Claude, GPT-4, etc.) at that provider's rates.

Can I run Open Science Desktop on a headless server?+

Yes, the osd command runs the full workbench without a GUI, serving the same web UI over HTTP. Download the osd archive from releases, configure with osd auth set and osd model set, then run osd server to start. The desktop installer also includes osd and adds it to your PATH automatically.

How do I install open-science?+

Open the source repository on GitHub and follow its README. open-science is a agent — MCP Agents Market links you directly to the official repo.

Is open-science free?+

open-science is an open-source project hosted on GitHub. Check the repository for its license and any usage requirements.

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